Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Metabolic activation pathway of acetaminophen. Generally, NAPQI is Download Scientific Diagram Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Frontiers Advances in the study of acetaminophen induced liver injury Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect