An integrative multi omics analysis leveraging Mendelian randomization and subsequent experimental validation prioritizes glutathione S transferase mu 5 (GSTM5) as a genomic stability related gene and a therapeutic vulnerability to PLK1 inhibition in Catabolism of extracellular glutathione supplies cysteine to support tumours Nature Glutathione in Cancer Cell Death Glutathione and Xanthine Metabolic Changes in Tamoxifen Resistant Breast Cancer Cell Lines are Mediated by Down Regulation of GSS and XDH and Correlated to Poor Prognosis Dual metabolic targeting liposomes potentiate triple negative breast cancer radiosensitivity via glucose and glutathione starvation ScienceDirect